Pdf mucoadhesive polymers for enhancing retention in. The major categories are wetting theory, adsorption theory, diffusion theory, electrostatic theory, and fracture theory. Formulation and in vitro evaluation of mucoadhesive. Here, we provide an overview of different mucoadhesive polymers with a focus on the relevance for the treatment of dry x syndrome. Xray diffraction study xrd the crystallinities of nevirapine and. Volume 39, issue 12, december 2014, pages 20302075. Design and in vivo evaluation of buccoadhesive hydrophilic. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers. Mucoadhesive polymers for enhancing retention in ocular drug delivery. The application of mucoadhesive polymers in nasal drug delivery systems has gained to promote dosage form residence time in the nasal cavity as well as improving intimacy of contact with absorptive membranes of the biological system. Buccal mucoadhesive drug delivery system pdf used for the preparation of mucoadhesive buccal patches. Specific processes include mechanical interlocking, electrostatic, diffusion interpenetration, adsorption. Design of mucoadhesive plga microparticles for ocular drug.
Formulation and development of mucoadhesive dental gel shital nishant shende 1. Formulation and development of mucoadhesive dental gel. Mucoadhesive tablets from each batch, under a constant weight of 5 g, were then placed onto the mucosal membrane for 1 minute. So far, a considerable number of studies focusing on the mucoadhesive. Bioadhesive polymeric platforms for transmucosal drug. The microspheres were prepared by the wo emulsification solvent evaporation method using mucoadhesive polymers sod.
Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic. Mucoadhesive polymers in the design of nanodrug delivery. Mucoadhesive polymers are of significant interest to the pharmaceutical, medical device, and cosmetic industries. Introduction opical application of drugs to the eye is the most popular and wellaccepted route of administration for the treatment of various eye disorders. Formulation and evaluation of mucoadhesive bilayer buccal tablets of labetalol hydrochloride using natural polymers ar. Mdds utilizes the property of bioahesion of certain watersoluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time. The present research mainly focuses on the screening of different mucoadhesive polymers for the development of mucoadhesive tablets with intestinal target. Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. Mucoadhesive polymers are versatile not only in their mechanisms of attachment, but also their origin. Mucoadhesive polymers in the design of nanodrug delivery systems for administration by nonparenteral routes. Feasibility investigation of cellulose polymers for. Quantitative evaluation of mucoadhesive polymers to. In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane.
The feasibility of various cellulose polymer derivatives, including methylcellulose mc, hydroxypropyl methylcellulose hpmc, sodiumcarboxymethylcellulose sodiumcmc, and cationichydroxyethylcellulose cationichec, for use as an excipient to enhance drug delivery in nasal spray formulations was investigated. Tablets were prepared by direct compression and evaluated for mucoadhesive strength and invitro dissolution parameters. In design and develop mdds are discussed with special emphasis on the mechanism. Mucoadhesive polymers are used to immobilize a drug delivery device on a speci. The bioavailability of ophthalmic drugs is, however, very poor due to efficient protective mechanisms of the eye.
The various new technology uses in development of nasal drug delivery dosage forms are discussed. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. Aiswarya and mohd azharuddin department of pharmaceutics, srinivas college of pharmacy, valachil, mangalore, karnataka, india. Polymers with thiol groups might represent a new generation of mucoadhesive polymers displaying comparatively stronger adhesive properties. It is proposed that the hydrogen bondforming capacity of the polymer is important in this effect, and may emphasize the welldocumented mucoadhesive properties of polymers possessing numerous carboxyl groups such as carbopol and polycarbophil. Therefore prolonged release of the incorporated drug scope.
Mucoadhesive polymers have recently gained interest among p harmaceutical scientists as a means of improving drug deliv ery by promotin g dosage from residence time and contact time with the. Mucoadhesive polymers are used to improve drug delivery by enhancing the dosage forms contact time and residence time with the mucous membranes. The present study involves preparation and characterization of mucoadhesive microspheres with famotidine as model drug for prolongation of gastric residence time. Mucoadhesive polymers have been developed for buccal, nasal, ocular, vaginal and oral applications. Although many studies report on chitosan being mucoadhesive, the nature of interactions between chitosan and mucin remains poorly defined. Evaluation of the mucosal retention properties and.
Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus. The mucoadhesive buccal films of ranitidine were prepared by solvent casting technique using polymers like hydroxy propyl methyl cellulose15 cps and poly vinyl pyrrolidone. Mucoadhesive polymers in the treatment of dry x syndrome. Development and evaluation of mucoadhesive buccal tablets. The compatibility of kt with various excipients was determined by ftir. Assessment of the mucoadhesive properties of mucolox using a 3d model of the human oral mucosa evaluation of the safety and toxicological profile of mucolox. A more specific term than bioadhesion is mucoadhesion.
Formulation and evaluation of mucoadhesive bilayer buccal. The mucoadhesive drug delivery system includes the following. The mucoadhesive polymers play the key role in determining the mucoadhesive ability of a dosage form. Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug. Samples 5mg each were accurately weighed into aluminum pans and sealed. The various mucoadhesive polymers used for the development of buccal delivery systems include cyanoacrylates, polyacrylic acid, sodium carboxymethylcellulose, hyaluronic acid, hydroxypropylcellulose, polycarbophil. It has been widely used for developing drug delivery systems because of its excellent mucoadhesive properties. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will. Human oral mucosa, nasal mucosa and vaginal mucosa part evaluation of the safety and toxicological profile of mucolox. To this aim a mucoadhesive layer, constituted by a single polymer or a blend of mucoadhesive polymers, containing the drug, was impermeabilised by a hydrophobic backing layer. Bioadhesive and mucoadhesive polymers authorstream presentation. Mucoadhesion, polymers, evaluation parameters introduction the termmucoadhesion bioadhesionis used to describe adhesion interactions between polymers and mucus or mucosal surfaces suresh et al. Mucoadhesive polymers mucoadhesive polymers are either water soluble or insoluble, derived from natural or synthetic source and are able to form several hydrogen bonds because of the presence of carboxyl or hydroxyl functional groups.
Hence, it is necessary to deepen the study of the polymers properties. Overview on buccal drug delivery systems pharmainfo. First generation mucoadhesive polymers anionic polymers polyacrylic acids carbomers, sodium alginate cationic polymers chitosan nonionic polymers cellulose derivatives hydroxyl, carboxyl or amine groups on the molecules favours adhesion formulation challenges due to hydrophilicity and limited solubility in other solvents. Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. Polyoxtm n 80 is one of the moderate viscosity grades while polyoxtm wsr 303 is highest viscosity grade. This makes the buccal cavity more suitable for mucoadhesive drug delivery. Formulation and evaluation of nevirapine mucoadhesive. Mucoadhesion may be defined as the process where polymers attach to biological substrate. Mucoadhesive polymers like carbopol 934p,sodium cmc and sodium alginate were used in. Mucoadhesive polymers are able to interact with mucus which is secreted by the underlying tissue. Mucoadhesive drug delivery system linkedin slideshare. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application.
Three main parameters for evaluating the polymers in nasal drug. Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting dosage from residence time and contact time with the mucous membranes. Adhesion of a matter to this layer is hence called mucoadhesion. Since the early 1980,the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. Polyethylene oxide polyoxtm is the good alternative of hpmc for the matrix system and shows the good swelling and mucoadhesive property. Polysaccharides possessing charged functional groups, such as chitosan, are known for mucoadhesive properties but suffer from poor chemical definition and solubility, while the chemical synthesis of polysaccharides is challenging with few reported examples of synthetic carbohydrate. In addition to factors related to the oral mucosa and oral environment features, the physicalchemical characteristics of mucoadhesive polymers must be also considered as factors influencing the. Dumore1 1dadasaheb balpande college of diploma in pharmacy, besa nagpur 2gurunanak college of pharmacy, nagpur need for injection would be a major advance in dental pain control, this research work was planned with there. All the ingredients including drug, polymer and other tablet excipients. Mucoadhesive drug delivery system is a part of controlled delivery system. A focus on mucoadhesive polymers and their application in.
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